A different approach to drug discovery

PharmaMar is conducting a multi-phase research program to discover and develop new antitumor compounds of marine origin.

Discover our unique approach to science

We are inspired by the sea, driven by science, and motivated by patients with serious diseases to improve their lives by delivering novel medicines to them. We intend to continue to be the world leader in marine medicinal discovery, development and innovation.

- Global marine expeditions finding new organisms
- Screen for anti-cancer properties
- Isolate, refine, synthesize, prioritize
- Robust in vitro and in vivo testing.

Simon Munt, Medicinal-Chemistry Senior Manager

Discover our unique approach to science

Production Facility

- 15,000m2 company facility in Madrid
- 4,600m2 R&D labs
- 3,000m2 GMP production area
- FDA, EMA, PMDA approved; no inspection deficiencies identified
- Secondary packaging and release capability

“We have achieved a solid and good reputation regarding quality”
Jose Luis Ortega, Director, Quality Unit

Production Facility

The scientific process

Performing basic research

A hypothesis is a conjecture

Performing basic research

Establishing a hypothesis, testing the hypothesis by carrying out experiments or collecting observations based on those predictions.

A hypothesis is a conjecture

Determine if the hypothesis was correct, and they are conducted under the auspices of the relevant healthcare authorities to ensure appropriate standards of patient care and safety.

Performing basic research

Performing basic research

Establishing a hypothesis, testing the hypothesis by carrying out experiments or collecting observations based on those predictions.

A hypothesis is a conjecture

A hypothesis is a conjecture

Determine if the hypothesis was correct, and they are conducted under the auspices of the relevant healthcare authorities to ensure appropriate standards of patient care and safety.

From seaside to bedside

PharmaMar conducts basic research with marine expeditions, compound isolation, chemical synthesis, and in vitro and in vivo studies to discover and develop new antitumor compounds of marine origin.

The marine expeditions are in accordance with all laws and ecological regulations of various governments, NGOs and others, and our extraction process involves extremely small sample sizes.

From seaside to bedside

The samples of these marine organisms are studied to learn their taxonomy and to assess their biological activity in tumor cells. We believe we have the world’s largest collection of marine organisms: over 250,000 samples of macro- and microorganisms.

If there is anti-cancer activity from the whole organism, we ‘fractionate’ so as to isolate the substance responsible for the activity, and its chemical structure is established.

Step by step

Our hypothesis is that marine invertebrates may have anti-cancer properties

DISCOVERY

RESEARCH

TESTING

CONFIRMATION

DISCOVERY

1. Our marine biologists go on expeditions all over the world.

2. They collect samples observing governmental and environmental laws.

RESEARCH

1. The sample is brought to our labs where it is tested for anti-cancer properties.

2. If there is anti-cancer activity, we try to isolate it within the sample.

TESTING

1. Once this fractionation isolates the compound within the sample that is responsible for anti-cancer activity, we test it in various well characterized cell lines.

2. We identify the mechanism of action.

3. We synthesize the compound. This is a complex process involving multi-disciplinary activities that may take years.

CONFIRMATION

1. If there is a significant effect on one or more cell lines, we will start other pre-clinical activities with the synthesized compound to see if these findings are confirmed.

2. Once the findings are confirmed, we optimize the dosing and indications before handing off the molecule to our clinical colleagues for testing in humans.

DISCOVERY

DISCOVERY

1. Our marine biologists go on expeditions all over the world.

2. They collect samples observing governmental and environmental laws.

RESEARCH

RESEARCH

1. The sample is brought to our labs where it is tested for anti-cancer properties.

2. If there is anti-cancer activity, we try to isolate it within the sample.

TESTING

TESTING

1. Once this fractionation isolates the compound within the sample that is responsible for anti-cancer activity, we test it in various well characterized cell lines.

2. We identify the mechanism of action.

3. We synthesize the compound. This is a complex process involving multi-disciplinary activities that may take years.

CONFIRMATION

CONFIRMATION

1. If there is a significant effect on one or more cell lines, we will start other pre-clinical activities with the synthesized compound to see if these findings are confirmed.

2. Once the findings are confirmed, we optimize the dosing and indications before handing off the molecule to our clinical colleagues for testing in humans.

We only pursue compounds if they possess a novel mechanism of action

We then undertake a chemical synthesis process for future medical purposes; all our clinical and commercial medicines are synthetic versions of the natural product.

At this point the usual drug development steps of in vitro and then in vivo testing can begin, leading hopefully to clinical trials to determine the drug’s safety and efficacy in various indications.

As a result of this research platform, we have a portfolio of products that are at various stages of clinical development.

We are prepared to carry out the development of our products consistently with rigor to the scientific process.

Even after a drug is approved, we don’t stop there, looking to expand our knowledge of other areas where we may be able to improve healthcare outcome.

Therapeutic Applications

PharmaMar was the first company in the world to develop a marine-based cancer drug from discovery through to commercialization.

Ovarian Cancer

Sarcoma

Multiple Myeloma

Small cell lung cancer

A team of experts

We are a multi-disciplinary team of biologists, chemists, clinicians, engineers, computer technicians, lab professionals, biostatisticians and more all working tirelessly towards one goal; to improve the healthcare outcomes of people afflicted with serious diseases.

  • More than 400 employees
  • 20 different nationalities; 15 languages
  • 65% university graduates and 18% PhD’s

Meet the team ->

Clinical trials

Clinical trials are part of the scientific process to determine if a hypothesis was correct, and they are conducted under the auspices of the relevant healthcare authorities to ensure appropriate standards of patient care and safety.

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