ZEPZELCA®

LURBINECTEDIN

Zepzelca® (lurbinectedin) selectively inhibits active transcription of protein-coding genes through binding to promoters and irreversibly stalling elongating RNA polymerase II on the DNA template, thereby leading to double-stranded DNA breaks and apoptosis. Lurbinectedin is an analogue of trabectedin however they have different properties.

The original marine source is a tunicate with a rounded, leathery body and two short siphons. It lives in shallow waters of around 6 meters on reefs, pilings and other hard surfaces in shallow waters usually on the submerged roots of mangroves. It can be found in the Caribbean Sea and Gulf of Mexico, as well as the Mediterranean Sea, and occasionally as far north as Chesapeake Bay. The walls of the individual zooids are known as tunics and are strengthened with cellulose, something unusual in animals. They use siphons to connect to their marine environments. The outer siphon surfaces are orange which is a colorful warning off to potential predators, as well as the sea squirt’s acrid taste.

Ecteinascidia turbinata is a simultaneous hermaphrodite with eggs and sperm being produced by each individual.

After fertilization, the eggs are brooded in the body cavity for about a week. Zepzelca® inhibit active transcription of protein-coding genes through binding to promoters and irreversibly stalling elongating RNA polymerase II on the DNA template, thereby leading to double-stranded DNA breaks and apoptosis.

Here's how it works

Lurbinectedin inhibits the active transcription of the protein encoding genes, provoking tumor cells death and normalizes the tumor microenvironment

Here's how it works

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Our Marketed Drugs

For over 30 years from it’s start in 1986, PharmaMar reinvested revenues or partnership income into R&D and building out the team.

TRABECTEDIN

Yondelis®

Treatment of patients with soft-tissue sarcoma and ovarian cancer.

PLITIDEPSIN

Aplidin®

Treatment of multiple myeloma.

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