APLIDIN®

PLITIDEPSIN

Welcome to the magical isle of Es Vedrà, an uninhabited rock island made of limestone situated 2 km off the southwest coast of Ibiza in the Mediterranean Sea.

Es Vedrà is shrouded in myths and legend, the most popular of which is that it is the third most magnetic spot on earth (after the north pole and the Bermuda Triangle). There is no evidence to support this though some report that navigational instruments are affected in the vicinity of Es Vedrà. Many other myths surround Es Vedrà.

Plitidepsin is extracted from the ascidian Aplidium albicans which to our our knowledge is exclusively found in the waters of Es Vedrà. This marine invertebrate is found at a depth of around 40-50 meters.

Plitidepsin is a cyclic depsipeptide, meaning it is a cyclic peptide in which there is one or more ester bond in place of one or more of a peptide bond.

Here’s how it works

Its mechanism of action is as an inhibitor of the eukaryotic translation eEF1A. In cancer cells this ultimately leads to cell-cycle arrest, growth inhibition and induction of apoptosis via multiple pathway alterations.

Here’s how it works

WE'RE HERE TO HELP

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We have a clear goal in mind: to make our therapies available in the shortest possible time for all appropriate patients.

We work with Healthcare Professionals and Patients, collectively and as individuals, as the focal point of a partnership.

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Our Marketed Drugs

For over 30 years from it’s start in 1986, PharmaMar reinvested revenues or partnership income into R&D and building out the team.

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SIDE EFFECTS AND ADVERSE EVENTS

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Communicating side effects and adverse events is a shared responsibility, where everyone is a key factor.

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